How does Interferon work Essay Example | Topics and Well Written Essays - 1000 words

How does Interferon work - Essay Example This paper aims to present the function and mechanism of Interferon Interferon, based on common definition is a family of cytokines or cell-signaling protein that is produced in the immune system. It functions as a natural protection of the human body which regulate anti-tumor, antiviral, and immune responses. Its function also includes cell differentiation (Ogbru par.1, 2). As stated in the article, Interferon is a drug resulting from biotechnology that is based from the protein found in our body. It is used as a drug against HIV/AIDS because it helps fight the symptoms of the disease. The mechanism of this drug was not understood before, therefore leaving it untouched and overlapped by modern treatments for HIV/AIDS that are available today. However, it was continuously used with other drugs in the treatment of hepatitis C which paved way to a better understanding of how interferon works (Bardi par.2-6). The explanation of how the interferon functions goes back to how the immune sy stem battles viruses. One way of how the immune system fights is by directly attacking or devouring the pathogens that are invading our body. Another way is with the use of the so-called restriction factors. The actions of the restriction factors are focused inside the infected cell in which they inhibit the spread or reproduction of the infected cells (Bardi par.1-3). APOBEC3, which is one example of these restriction factors, is also a family of proteins that thwarts the production of infected cells. It is indicated that APOBEC3 have eight genes that are present in humans and other primates. APOBEC3 is another family of protein that is connected to the protein named Activation Induced Deaminase (AID). AID is required in somatic hypermutation and class switch recombination. These processes are required to perform its function in DNA mutations on bacteria. APOBEC3 uses the same concept in disabling HIV infected cells. They attach themselves to the infected producer cells mutating it . This mutation affects the infected cell by packaging APOBEC3 into virions of flawed virus. The budding virus that would be produced will make them unable to infect new cells (Bardi par. 4; Doehle 14 & 16). Although APOBEC3 disables the production of infected cells, the HIV has developed its own defenses that would retaliate against APOBEC3. These things are called viral infectivity factor or Vif. Vif destroys APOBEC3 by taking over parts of the cellular ubiquitin-proteasome pathway. After seizing the cellular degradation pathway, the Vif targets the APOBEC3. Dilapidation happens after the polyubiquitination of APOBEC3 molecules. This would then disable the job of the APOBEC3 to be packaged in budding viruses, making them target and infect new cells (Bardi par. 11; Spearman 1, 2 & 11). Tetherin, another member of the restriction factors also help in the prevention of infected cells and HIV. Tetherin is also identified as HM 1.24, CD317 and bone marrow stromal antigen or BST-2. It i s a type 2 transmembrane protein and consists of a cytoplasmic N-terminal region, a transmembrane domain, a flexible coiled-coil extracellular domain and a C-terminal glycophospatidyl-inositol anchor. The discoverers of tetherin also described it as a membrane spanning protein. Tetherin, which is derived from the word tether literally tethers, or secures the virions on the cell membrane of the infected c

Women fce greter chllenges thn men in their ttempts to climb to the Essay

Women fce greter chllenges thn men in their ttempts to climb to the top of the corporte ldder - Essay Example More recently, however, there hs been n influx of women into non-trditionl, higher sttus occuptions, nd it ppers tht trditionl ptterns of occuptionl segregtion my be slowly chnging. It is considered, tht women fce greter chllenge thn men in their ttempts to climb top of the corporte ldder. This suggestion hs been mde due to historicl chnges tht took plce in the distribution of gender workforce nd will be discussed lter in this pper. lthough women nd men hve lwys engged in purposeful ctivity, the set of ctivities tht mny people consider work or employment is not lwys cler. Historiclly, men nd women worked side by side together in the fields. Tody, however, distinction is mde between pid, public work externl to the fmily nd unpid, privte work in the home. Ech of these spheres of work hs come to be sex-typed, with pid work being viewed by mny s the domin of mles nd unpid work in the home the domin of femles. These perceptions re chnging but re still deep-seted in mny respects. Historiclly, men nd women hve hd very different experiences of work. Men hve either secured goods or worked externl to the fmily unit, wheres women often hve worked more integrlly s prt of tht unit. Beginning with industriliztion nd continuing to the workplce tody, men's nd women's experiences of work hve vried significntly, lrgely due to the continuing sex segregtion of occuptions. However, with the onset of two world wrs, both Blck nd White women stedily incresed their numbers in the externl, pid workforce. During the 1990s, the mjority of both men nd women, Blck nd White, were employed outside of the fmily unit. The reltions between men nd women - sometimes chrcterised s "wr" - hve since been trnsformed. In the City of London tody, for exmple, some highly pid expectnt mothers ttempt to time their bonus pyments so tht they fll within the reference period used to clculte mternity py entitlements. If they mnge to win bonus between 18 nd 26 weeks before their expected birth dte, they cn receive mternity py mounting to much more thn they ern normlly - nd with the pprovl of the Inlnd Revenue. How much of this chnge is due to the lw, nd how much would hve hppened nywy becuse of economic nd lbour mrket pressures It is, s lwys, difficult to sy. Yet most commenttors rgue the SD hs hd significnt impct on British working culture. "Tody, it is unusul for women to be discriminted ginst directly becuse they re women, which is wht used to hppen," sys Michel Rubenstein, the founder of Equl Opportunities Review, specilist journl. "The discrimintion tht tkes plce now is mostly round women's fmily roles nd resentment of the disruption it cuses." (Overell, 2006). Jmes Cox, n employment prtner t shurst, n interntionl lw firm, sys: "The City [of London] is the lst bstion of old-style employment prctices, where the focus is on working hrd nd ceding your life to your employer nd clients. "But in the lst few yers it hs been hit relly hrd by women tking [employers to] tribunls nd sometimes wlking wy with multimillion-pound compenstion pyments. It is those cses of the lte 1990s, directly due to the SD, tht hve forced the City to chnge its wys." (Overell, 2006). It is only in very recent yers tht there hs been notble rise in the number of people (mostly women) using sex equlity lw to chllenge employers. In 1998-99, 6,200 women took their employers to tribunl; by 2003-4 the figure hd risen to 17,000 people